We propose that close proximity favors transfer to the immediately adjacent pole and that concentration of SpoIIE in the forespore, which is almost entirely derived from the pole, promotes multimerization.
(D ) Model for handoff of SpoIIE from the divisome to the adjacent cell pole.
Upon the completion of cytokinesis, SpoIIE transfers to the adjacent cell pole where multimerization protects it from proteolysis (as depicted by the light orange Tags) and leads to phosphatase activation.
We present evidence that the upstream regulator of σF, the phosphatase SpoIIE, is compartmentalized in the small cell by transfer from the polar septum to the adjacent cell pole where SpoIIE is protected from proteolysis and activated.
In summary, we propose that the asymmetrically positioned division machinery – the de novo-generated source of asymmetry – positions SpoIIE to be captured at the adjacent cell pole, triggering σF-directed gene expression in the forespore.
Here we have provided evidence for a model in which SpoIIE leverages the asymmetric position of the septum to selectively associate with the adjacent cell pole of the forespore where it is stabilized and activated.
For bar magnets, demagnetization can be minimized by keeping them in pairs, laid parallel with north and south poles adjacent and with a soft-iron keeper laid across each end.
Follow-up brain MRI (two months later) revealed the presence of pathologic tissue with homogeneous enhancement in both ganglia of Gasser cisterna along the course of the trigeminal nerve, associated with thickening of the dural surface and adjacent the temporal pole, suggesting granulomatous or lymphoproliferative disease.
Varied abnormalities in the temporal lobe and pole adjacent to HS in patients with mesial temporal lobe epilepsy have been described, including mild dysplasias (previously called microdysgenesis) to FCD I [ 23, 53].
