The phrase "adjacent modifications" is correct and usable in written English.
It can be used in contexts where you are discussing changes or alterations that are next to or related to each other, often in technical or academic writing.
Example: "The adjacent modifications in the design improved the overall functionality of the product."
Alternatives: "neighboring changes" or "contiguous adjustments".
While negative regulation by an adjacent modification has not been reported for BRDs, it has been shown that the sequence specific histone H3 recognition by the BHC80 PHD finger binding to non-modified H3 is attenuated upon methylation of H3 lysine 4 in gene transcriptional repression [34].
Overlapping binding interfaces promote competitive binding by engaging in mutually exclusive interactions, whereas overlapping or adjacent modification sites allow modulation of a binding interface by a modification event.
Moreover, the presence of an adjacent modification might prevent binding of an antibody to the target modification, causing false negative results.
I will explore within this short review the cross-talk between cis lysine methylation sites and other adjacent posttranslational modifications within histones H3 (Fig 1) and H4 as well as a few non-histone proteins.
We investigated how Lys49 acetylation on β-catenin affected the adjacent posttranslational modification sites in the N-terminal regulatory domain.
Evolution of cryotherapy for prostate cancer is likely to result in parenchyma-sparing modifications adjacent to the urethra and neurovascular bundle.
In addition, further post-translational modifications adjacent to the acetylated lysine might alter the epitopes for proper readout by an antibody.
On the other hand, the apparent distribution of CTD isoforms along the gene in other organisms varies greatly depending on the antibody in use and the presence/absence of modifications adjacent to the epitope (summarized and extended in [ 17]).
The dihydroimidazole analogs feature a modification adjacent to the primary tissue-bound peptidase hydrolysis site that is expected to enhance biostability over natural PK peptides identified by peptidomics.
