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This pilot study was designed to determine the safety and efficacy of 166Holmium (Ho -DOTMP for irradiating malignant cells and adjacent marrow in women witHo -DOTMPly metastatic breast cancer.
In the acute phase there is often edema of adjacent marrow and soft tissues which intensely enhances with gadolinium.
New bone on the surface of these trabeculae was seen in 2 cases in both cases close to membraneous ossification in the adjacent marrow.
However, we have recently observed that the adjacent marrow signal may vary considerably and may even be increased on T1SE MRI suggesting tissue metaplasia.
Backfill is the term we gave to this appearance of new tissue with high signal on T1WSE MRI that is clearly demarcated from adjacent marrow by an irregular dark signal reflecting sclerosis.
Previous descriptions of erosions on T1SE MRI have cited complete breech in subchondral bone with change of adjacent marrow signal as defining characteristics of an erosion [ 6, 7, 11].
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We have defined erosion as a full thickness breach of cortical bone together with loss of the adjacent bright marrow signal on T1WSE scans, indicating replacement of normal fatty marrow by inflammatory tissue.
They represent vertebral endplate and adjacent vertebral marrow changes on magnetic resonance imaging (MRI), classified into three types.
Mesenchymal stem cells (MSC) from adjacent bone marrow represent a candidate cell source.
One ankle had a small accessory navicular ossicle, but without adjacent bone marrow edema.
Presences of accessory ossicles were recorded along with any adjacent bone marrow edema.
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