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The growth of blood capillaries indicated that the regenerated adipose-like tissue was living tissue.
Adipose-like tissue regeneration was only observed in the mice injected with cell-encapsulated PP hydrogel.
The transplantation of isolated and cultured preadipocytes within a standardised collagen matrix resulted in well-vascularised adipose-like tissue.
Immunohistochemistry analysis with mouse anti-human nuclei monoclonal antibody demonstrated that the cells in the regenerated adipose-like tissue was originated from the injected hASCs.
The defect in lipolysis in PML-deficient HBsAg-transgenic mice made the HBsAg-induced adipose-like liver tumors vulnerable to synthetic lethality from toxic saturated fat accumulation with a Scd1 inhibitor.
In either case, an appropriate operative field is of paramount important because liposarcomas often have ill-defined borders: because they contain a high proportion of adipose-like tissue, it is sometimes difficult to distinguish tumor-related adipose tissue from normal adipose tissue [9].
The concept of interconvertibility is appealing because in vivo the bone marrow progressively adopts a more 'fatty' or adipose-like, versus hematopoietic, structure as a function of age.
As such, it is a dramatic advance for a field that has generally ignored the role of intestinal yolk and simply interpreted all lipids in the intestine as the equivalent of adipose-like storage depots.
Stellate cell activation is a key event in liver fibrosis, and it involves the process of transition of a quiescent, adipose-like vitamin-A storing cell to a highly fibrogenic cell [ 41].
Long-term studies suggested that enzymatically degradable hydrogels furthermore promote the formation of coherent adipose tissue-like structures featuring many mature unilocular fat cells.
These findings demonstrate that overexpression of PeriA in white adipocytes reduces lipid droplet size by decreasing FSP27 expression and thereby inducing a brown adipose tissue-like phenotype.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com