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However, when both homophilic adhesions are stronger than the heterophilic adhesion, which corresponds to the "specific adhesive relationship", the DAH model predicts that the "inside and outside" configuration of cell-sorting does not occur.
This adhesive relationship predicts that homophilic adhesions of both cell types are stronger than heterophilic adhesions, as observed in many experiments [ 4- 8].
His Tonto, of course, had an adhesive relationship to the objective case.
In the above Glazer's study (1992 , 1993, this "specific adhesive relationship" was not examined.
When one homophilic adhesive relationship (for example, between A and A) is strongest, the other homophilic adhesive relationship (for example, between B and B) is weakest, and a heterophilic adhesion (between A and B) is intermediate, the DAH predicts that these conditions are sufficient to generate the "inside and outside" configuration of cell-sorting [ 10].
Thus, we reproduced their model (Additional files 1, 2), examined the final configurations of cell-sorting, and confirmed that the "inside and outside" configuration was not attained under the "specific adhesive relationship" with the DAH model (Additional File 3).
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Secondly, a numerical procedure allowing for non-linear adhesive stress strain relationships to be accounted for is presented.
We utilized this model to quantitatively assess the relationship between adhesive forces derived from cell substrate interactions and the ability of fibronectin fibril assembly to induce cellular self-assembly.
It is then possible that upregulation of tyrosine phosphorylated proteins and downregulation of cadherins and integrins in human primary melanoma cells that overexpress Nck2 may endow melanoma cells with altered adhesive properties and spatial relationships that favor uncontrolled proliferation, migration and invasion.
In the case of one-component moisture-curing polyurethane (1C PUR) adhesives, knowledge about relationships between their chemical structure and the resulting bonding properties is limited, especially under high-temperature conditions.
The relationship between highly adhesive SAMs and bacterial inactivation may be useful in future biomaterial design.
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