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Mesenchymal stem cells quickly anchored to the hybrid matrix, forming focal adhesions, and substantially conformed to cytoskeletal extensions, benefited from the fibronectin adhesive domains.
In Plasmodium falciparum, a family of six secreted proteins having a conserved architecture of multiple adhesive domains was recently identified by genome annotation.
The thrombospondin-related anonymous protein (TRAP) of Plasmodium sporozoites is directly involved in both processes and shares conserved adhesive domains with micronemal transmembrane proteins of other apicomplexans.
Fig. 8 Common methods used for the QD biofunctionization including: (a) direct linkage to the TOPO-coated QDs [biomolecules can be linked including thiolated DNA (ligand exchange)] or peptides with adhesive domains, (b) electrostatic interaction, and (c) covalent linking (Xing and Rao 2008).
The adhesive domains used in this study are both structurally and functionally conserved across life.
To our knowledge, this is the first description of a dense granule protein containing adhesive domains.
Similar(39)
The oligopeptide CCRRGDWLC was designed to contain a cell adhesive domain (RGD) in the center and cysteine residues at both terminals.
It has been shown that E. coli ORN178 binds specifically to d-mannose, which is an integral part of the glycoproteins that are a part of the adhesive domain on host cells (Sharon 2006).
We therefore tested the subcellular localization of several candidate adhesive domain-containing proteins in this system.
The first step was to computationally identify candidate apicomplexan adhesive domain-containing proteins, utilizing Pfam domain patterns present in known microneme proteins (Fig. 1).
ADAM proteins are membrane-anchored glycoproteins named for two of the motifs they carry: an adhesive domain (disintegrin) and a degradative domain (metalloprotease) [135].
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