NRG1α-induced adhesion variation is blocked by erbB2, PI3K, and Akt inhibitors, but not by PLC, ROCK, MLCK, or MEK inhibitors, implicating the erbB2/PI3K/Akt1 signaling pathway in NRG1-stimulated, integrin-mediated cell adhesion.
Diagram of adhesion force variation for normal thin PS films under different temparatures: e 403 K and f 298 K.
Moreover, the film thickness dependence of T g for normal thin PS films is calculated by monitoring the adhesion force variations.
When we commenced this work, we hypothesized that the FIKK proteins could be involved in the process of IE adhesion and antigenic variation of var genes, since this process is unique to P. falciparum.
Given that most of the Pf fikk genes were shown to be transcribed in blood stages [17] and N-terminal regions are unique to each paralog, this raises the possibility that each FIKK protein might have different functions in the IEs and that other FIKK proteins could have other biological roles including trafficking, adhesion and antigenic variation.
Due to the fact that the bulk volume affects the surface chemistry, which functions as contact zone where adhesion takes place, variations in the cross-linking density could generate (for example, in polar surface groups) if respective end groups are available due to an incomplete reaction.
As suggested by the co-localization of actin and paxillin within the FA, the forces exerted by actin stress fibers may differ at either end of the adhesion, resulting in variations in the exchange dynamics of FA plaque proteins (Figure 7).
We show here compositional variations between adhesion sites, as well as ordered variations along the axis of individual focal-adhesions.
The variation in adhesion classifications, mode of application of agents, lack of uniformity in surgical approaches and variations in the interpretation of results all make the assessment of the efficacy of the many agents difficult and almost impossible to compare.
The maximum range of variation in adhesion over sixty minutes correlates strongly with NRG1α-induced migration (r2 = 0.61).
