The test method is fast, robust and has a potential for multi-purpose: static adhesion, bond durability, surface and adhesives screening and, ultimately, it can be used as in-process test coupon for manufacturing control of composite bonded parts.
To identify plasma-borne endogenous SR-A ligands that contribute to SR-A-mediated macrophage adhesion, we screened human plasma for candidate ligands and tested their ability to sustain macrophage adhesion.
This model could be easily prepared and gave a rate of adhesion formation of 90%, which was useful for screening antiadhesive materials.
While screening prostate cancers for CXCL12-responsive adhesion molecules, we identified CD164 (MGC-24) as a potential regulator of homing.
In order to screen for adhesion receptors putatively involved in human endometrial adhesivity to blastocysts, we directly measured plasma membrane expression of adhesion receptors by means of a flow-cytometry based array that included specific monoclonal antibodies directed against 40 different adhesion receptors.
Screening the S288c library and the comparable Sigma deletion library for adhesion uncovered 599 deletions with decreased adhesion (Ahs −) (Table S1, Table S2, and Table S3).
Therefore, the developed coculture would be a potential assay for screening novel drugs to inhibit the liver-microvasculature specific adhesion of cancer cells.
Scratching and indentation on the nanoscale are powerful ways to screen for adhesion and resistance to deformation of ultrathin coatings.
Polymer pen lithography was recently used to create arrays of fibronectin patches of different sizes, based on the pressure and angle of the thousands of polymer pens depositing the fibronectin, to systematically screen MSC adhesion to different patch sizes [ 56].
After screening, peptide MSP68 (VRGDV) had the highest inhibition of dHL-60 cell adhesion to fibronectin by 55.8%% and to PAEC by 67.7%%.
