Recent studies show that uPAR itself is a high-affinity adhesion receptor for vitronectin and that urokinase (uPA) is an activator of this adhesive function.
Jackson, S.P. et al. Adhesion receptor activation of phosphatidylinositol 3-kinase.
Munshi, H. G. & Stack, M. S. Reciprocal interactions between adhesion receptor signaling and MMP regulation.
Odievre, M. H. et al. Modulation of erythroid adhesion receptor expression by hydroxyurea in children with sickle cell disease.
Jacquemet, G., Humphries, M. J. & Caswell, P. T. Role of adhesion receptor trafficking in 3D cell migration.
Berendt, A.R., Simmons, D.L., Tansey, J., Newbold, C.I. & Marsh, K. Intercellular adhesion molecule-1 is an endothelial cell adhesion receptor for Plasmodium falciparum.
In contrast, the β1 integrin adhesion receptor played only a minor role on cell polarity.
We propose that adhesion receptor polarization is a parenchymal immune checkpoint that allows functional epithelium to hamper leukocyte binding.
Additionally, integrin αvβ3, an adhesion receptor expressed in osteoclasts (OCs), was implicated in the regulation of OC function via regulation of the cytoskeletal organization of OCs.
E-cadherin is the major adhesion receptor in epithelial adherens junctions, which connect cells to form tissues and are essential for morphogenesis and homeostasis.
In this study, we have used a tractable 3D co-culture model to explore the functional role of the α6β1 integrin adhesion receptor on BMSCs in sprouting angiogenesis.
