Exact(4)
These include: Calcium binding (module 2); cell adhesion (module 3); and metallopeptidase activity (module 4).
The four fasciclin (FAS1) domains, described as a cell adhesion module [ 23], are encoded by exons 3 to 14.
Genes belonging to these modules were related to processes such as the regulation of cytoskeleton organization, growth (Module E), biological adhesion (Module F), anatomical structure morphogenesis, and cell junction organization (Module G; Table 1).
SAs have a modular structural organization resembling that of natural E. coli adhesins, which are commonly composed of an anchor β-barrel module that is embedded in the bacterial outer membrane (OM) and an adhesion module bearing an immunoglobulin (Ig -like fold that Ig -likeed to the extracellular milieu.
Similar(56)
Recently, the G5 domains were found to be zinc-dependent adhesion modules and a "zinc zipper" mechanism was suggested for G5 domain-based intercellular adhesion in SasG- or Aap-mediated biofilm accumulation [42].
(i) While TRAP contains classical adhesion modules, namely an A-domain and a TSR, in its extracellular portion, the extracellular region of S6 appears to be lacking any typical adhesion modules.
The adherens junctions are the best known cell-cell adhesion modules which are responsible for the strong mechanical intercellular adhesion, especially in epithelial tissues.
(ii) The large extracellular portion consists largely of low-complexity regions and lacks apparent cell adhesion modules, such as TSRs and A-domains.
PfEMP1 has a large extracellular domain with a sequence of six adhesion modules called Duffy-Binding Like (DBL) domains DBLα, β, γ, δ, ε and X (Mercereau-Puijalon et al, 2008; Rowe et al, 2009).
Related ZU5 domains are also found in several other large bacterial cell surface proteins, which additionally contain diverse adhesion modules and other enzymatic domains, such as glycohydrolases, lipases and phosphodiesterases (Additional File 1).
The genes returned in the Collagens search may represent a conserved cell-adhesion module.
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