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According to differential adhesion hypothesis (DAH), the differences in intercellular adhesiveness between different cell types can drive the movement and assortment of cells.
Differential adhesion hypothesis.
One is the differential adhesion hypothesis (DAH), developed by M. Steinberg (1962a); (1962b); Steinberg 1963; Steinberg 1996) postulating that tissue surface tension is proportional to the intensity of adhesive energy between point object cells.
To study cell sorting events Belmonte et al. (2008) developed a model combining the Vicsek Model of collective motion (Vicsek et al. 1995; Vicsek & Zafeiris 2012) with the differential adhesion hypothesis (DAH).
According to the differential adhesion hypothesis, cells begin to coalesce at this stage to minimize the free energy within the biological system.
We propose that the early stages of tissue development within the self-assembling process are mediated by cadherin-cadherin interactions, as described by the differential adhesion hypothesis [42].
Similar(34)
To investigate this hypothesis, adhesion, transendothelial penetration and NCAM (CD56) adhesion receptor expression of drug-resistant versus drug-sensitive NB tumor cells were evaluated.
Such targeting increased homotyptic adhesion supporting the hypothesis that sialophorin facilitates the breakup of primary tumours such that they shed potentially metastatic cells.
In general, the Irf6+/R84C; Jag2+/smicecexhibitedevenven less extensive oral epithelial adhesions, supporting the hypothesis that the sm mutation, which is a Gly267Ser mis-sense change in the first EGF repeat of Jagged2, is a hypomorphic allele of Jag2 (26, 33, 36).
These results further strengthen our hypothesis that adhesion signals mediated by ligand-bound integrins are required to maintain eIF2α phosphorylation at basal levels.
In support of this latter hypothesis, cell adhesion molecules such as ICAM-1 are known to modulate the JNK/AP-1 signaling pathway.
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