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CLU is a sulphated glycoprotein, implicated in various cell functions involved in carcinogenesis and tumor progression, including cell cycle regulation, cell adhesion, DNA repair and apoptosis.
Multiple transcripts (n≥3) were also involved in the processes of apoptosis; cytoskeleton and cell adhesion; DNA; proteolysis and protein degradation; and translation and protein biosynthesis.
Categories included: apoptosis; cell proliferation, growth and development; cytoskeleton and cell adhesion; DNA; electron transport and oxidative phosphorylation; metabolism; proteolysis and protein degradation; regulation of transcription; response to oxidative stress; response to stress; RNA; signaling; translation and protein biosynthesis; and transport.
Examples include genes implicated in cell adhesion, DNA repair, and apoptosis that can be downregulated by DNA methylation.
We identified several regulated proteins to be important in subnetworks that among others are involved in focal adhesion, DNA replication, apoptosis, and insulin and HER2 signaling pathway.
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Focusing on overexpression (Fig. 4), especially genes involved in cell cycle, PI3K-AKT, TGF-Beta, focal adhesion, notch, DNA replication and DNA repair pathways were significantly affected by overexpression in AS II, AS III or GBM IV.
In this platform, osteoblasts on ZnO nanoflowers showed stronger adhesion, more DNA content and higher ALP activity than those on the flat ZnO surface.
39 These bioactive molecules include growth factors, proteases, adhesion molecules, DNA and microRNAs.
We briefly summarized the epigenetically silenced TSGs in ESCC according to their biological functions, such as apoptosis, cell cycle control, cell adhesion, and DNA repair (Table 1).
However, adhesion of DNA to the nanopore surface delayed the release of the trapped conformation and caused stochastic stalls during the free translocation phase of the pulse.
PDI enzymes are found in other subcellular compartments and are thought to participate in or modulate a range of functions, from cell adhesion to DNA binding [ 10- 12].
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