While FAK signaling had some impact, our results suggested that Pyk2 can regulate both gene expression and endothelial sprouting through its enhanced activation by VEGF in limited adhesion contexts.
Therefore, both the literature and our observations suggest the unique nanotopography of the ATT surface might have played a crucial role in cell adhesion in this context.
These results document that distinct functions can be assigned to the chemokine receptors (CXCR4 migration, CXCR7 adhesion) in the context of platelet-derived CXCL12.
Successful metastasis requires a degree of active focal adhesions in the context of an anoikis-resistant anti-apoptotic signaling mechanism.
We discuss models for the force-induced dissociation of a ligand-receptor bond, occurring in the context of cell adhesion or single molecule unbinding force measurements.
In this context, the adhesion of two organic submicron thin films, semi conducting and dielectric respectively, deposited on polymeric substrate were investigated by scratch test method.
In the context of adhesion, migration and invasive behaviour, it has been shown that the integrin glycan composition is important for its structure, function and activity.
In this context, the adhesion ability to the intestinal epithelium, which is considered to be a prerequisite for colonization, is an important criterion for the selection of probiotic bacteria [ 34].
Spontaneous omental haemorrhage is a rare entity that is usually preceeded by trauma or occurs in the context of adhesions, neoplasms or anticoagulation.
We have therefore investigated dystroglycan function and the potential interactions mediated through these sites in the context of adhesion-mediated signalling.
Matrix metalloproteinases (MMPs) and "a disintegrin and metalloproteinase" (ADAM) family of proteins are representative proteases that mediate ectodomain shedding, and this process regulates the biological activities of diverse proteins, including growth factors, cytokines, receptors and cell adhesion molecules in a context-dependent manner (Blobel, 2005; Seals & Courtneidge, 2003).
