This information, together with our finding that there was little difference in susceptibility between biofilm-grown bacteria and planktonic-grown bacteria of the same density, suggests that a densely adherent growth mode is an important determinants of biofilm resistance.
c Values underlined indicate a significant increase in the MICs or MBCs between log-planktonic and adherent monolayer modes of growth.
In agreement with the study by Labthavikul et al. (2003), we found that MICs and MBCs were generally similar when CoNS were grown in the planktonic mode or as adherent monolayers [ 41].
A recent study has reported that a murine ESC-derived NSC line (LC1) is propagated as an adherent homogenous culture with a dominant mode of symmetrical self-renewal [21].
We distinguished the above-mentioned subgroups from non-adherent patients who discontinued the planned mode of treatment and refused to continue further endocrine therapy.
However, most biofilm-positive, but few biofilm-negative isolates were more resistant to vancomycin (increased MICs) and rifampicin (increased MBC) in the biofilm mode than planktonic cells or adherent monolayers (Tables 2 and 3).
It's all very much in the handcrafted, start-from-scratch mode that is gaining many adherents now, particularly in film, but which this artist has been exploring for years.
We are all discussing about something similar to a "paradigm shift", in the sense described by Kuhn [3]: (a) presenting results "sufficiently unprecedented to attract an enduring group of adherents away from competing modes of scientific activity" and (b) "being sufficiently open-ended to leave all sorts of problems for the redefined group of practitioners to solve".
Comparison of these cell line-specific subproteomes reveals proteins with functions that highlight not only the differences in lineage, but also distinguish mode of culture, for example suspension vs adherent culture.
