Specifically, baseline similarity, equal dose and frequency of co-interventions, compliance, adherence to intention-to-treat analysis, and timing of outcome assessment were compared between the groups.
We recorded randomization methods, allocation concealment, blinding, frequency and handling of missing data, adherence to intention-to-treat analysis, and selective outcome reporting.
15 The domains used in the present systematic review pertained to randomisation and allocation concealment (selection bias), blinding (performance and detection bias), and adherence to the intention to treat principle (attrition bias).
5 34 Therefore it is difficult to determine from published information whether reported exclusions from the analyses resulted in bias, 2 and strict adherence to the intention to treat principle should be advocated.
Reviewers assessed study validity and applicability by appraising concealment of allocation, blinding, handling of withdrawals, cointerventions, compliance, similarity of timing of outcome assessment, and adherence to the intention to treat principle.
Two authors (KEAB, NKJA), not blinded to the source of the reports, used a standardised data abstraction form to independently abstract data regarding study methods (randomisation, allocation concealment, cointerventions, blinded outcome assessment, completeness of follow-up, and adherence to the intention to treat principle).
29 Two reviewers independently assessed the methodological quality of each eligible study by using the following criteria: concealment of allocation; blinding of patients, caregivers, or clinical outcome assessors; adherence to the intention to treat principle; stopping early for benefit; and the proportion of patients lost to follow-up.
With respect to fidelity, documenting adherence to the designers' intentions and the nature of adaptations is a more straightforward endeavor for specified programs with explicit goals.
The interview topics included sexual desire before and after commencement of ART, attitudes towards sex and condom use, fertility intentions, adherence to ART, disclosure of HIV status and concerns about HIV transmission.
All patients were included in the analysis regardless of subsequent adherence to treatment, according to the intention to treat principle.
A stronger intention toward adherence to the fruit recommendation was the only significant correlate in explaining a higher fruit consumption (p = .000).000
