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RESULTS: Each intervention produced adherence proportions that ranged from 72%to76%6%.
Adherence proportions were analyzed with the non-parametric Cochran's Q test, using cut-off values of VTe ≤ 8.0 mL kg.
We considered the causal relative risk, comparing the effect of different adherence proportions on the probability of virologic failure.
We first estimated the causal effect of different adherence proportions on the probability of virologic failure, conditioned on duration of continuous viral suppression (Figure 1).
Median adherence proportions in cross-sectional studies were 74.3% (Range 25 88%) for papers alone and 73.6% when the three conference abstracts were added.
Based on univariate regression analyses, participants who had longer duration of suppression also had higher CD4+ counts, higher CD4+ nadir, and higher cumulative average adherence proportions.
Similar(47)
We examined antipsychotic spending using linear models, adherence (proportion of days covered >80%) using logistic models, and nonpersistence (time to first gap in antipsychotic use >30 days) in 2009 using Cox proportional hazard models, comparing beneficiaries with versus without generic use, adjusting for individual and plan characteristics.
Calculations included average adherence (proportion of prescribed doses taken), dosing errors (number of overdosing or underdosing events in 24 hours), and proportion of doses taken on schedule (doses taken within 2 hours of prescribed dosing interval).
While the adherence proportion required to sustain viral suppression may decline over time, the goal of near perfect adherence should remain unchanged.
Because adherence proportion cannot be randomly assigned as an intervention, we relied on a marginal structural model and targeted maximum likelihood estimation of the causal effects of adherence on viral suppression at each time point.
We stratified subject-months by corresponding duration of suppression and then estimated the probability of virologic failure setting the adherence proportion to be in the ranges (0 49%, 50 74%, 75 89%, and 90 100%).
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