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Breast cancer sphere images clearly demonstrate the adherence of multiple spheres forming bigger size spheres.
Confocal microscopy was performed, which highlighted the adherence of multiple spheres forming bigger size spheres as observed previously (Fig. 1a).
Bortezomib has been reported to alter the adherence of multiple myeloma cells to ECM proteins and bone marrow stromal cells [ 36], and to disrupt cell adhesion in spheroids derived from an ovarian cancer cell line [ 24].
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A review of anti-hypertensive medicines found that the adherence rate for a single daily dose was significantly higher than adherence to multiple daily doses.
The use of multiple adherence measures allows examination of both intentional and unintentional non-adherence, as prescription refill, FMD and TDA data provide a quantitative estimate of non-adherence whilst the MMAS provides some information about the reason for the non-adherence.
This study applied a uniform methodology for measuring and comparing duloxetine adherence in the treatment of multiple chronic medical conditions.
Although several economic studies assume high levels of adherence, multiple observational studies and trials have shown that this assumption is often incorrect with prescribers still prescribing an antimalarial despite a negative test result.
In sensitivity analysis, our findings were robust to a modified threshold of adherence, multiple imputation for missing data and aggregate level data pooling, but not to fixed-effects meta-analyses using generalised estimation equations.
Participants' demographic characteristics are presented in Tables 1 and 2.>> In 40 intervention groups, the efficacy of only one adherence-enhancing component was tested against a control group, whereas in 47 intervention groups a combination of multiple adherence-enhancing components was tested (Fig. 2).
In fact, we know of but two studies published within the past 25 years that attempted direct comparisons of adherence across multiple chronic medical conditions.
We also assessed factors associated with misreporting of adherence using multiple drug-concentration thresholds and explored pill use and misreporting using semi-structured interviews (SSIs).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com