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In our study, medication non-compliance was the principal leading cause of ICU admissions due to preventable ADE (30%%), showing that adherence failure might also generate severe outcomes and a significant burden for the healthcare system.
Adherence failure was common because of a variety of factors and not just because of concerns about drug side effects.
The extant research shows that reduced compliance is associated with overly complex routines, as over 74% of the participants in one particular study (Topinkova et al 2006) self-reported a memory lapse as the primary reason for adherence failure.
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Most adherence failures occur early in the course of treatment.
Our methods preclude examining the predictors and impacts of these early adherence failures.
It is known that most adherence failures occur early in the course of treatment [ 7, 8].
However, occasions on which a patient opened less than the prescribed dose frequency were considered as adherence failures.
The literature on CONSORT adherence failures is extensive and is developing similarly for the CONSORT-NPT extension.
Moving to adult care can be challenging for adolescents with a long-term condition; if not managed well it may result in non-adherence, failure to attend appointments and a decline in health post-transfer.
16, 17 For each intervention group, three models of regression were used to explain adherence or failure to adhere.
Physicians treating headache sufferers should acknowledge nocebo as a significant cofactor for treatment adherence and failure and plan techniques to border nocebo, such as patients' education and close follow-up.
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