Despite the adherence benefits of LAI antipsychotics, there is still considerable resistance to their first-line usage [ 31- 33].
This finding suggests that a subgroup of patients with low adherence benefits from the adherence-enhancing intervention as suggested by Simons et al 25 However, a certain number of patients cannot be reached and reveals a resistant medication taking behaviour.
Such strategies form the mainstay of current medication adherence interventions, and so our research suggests that CBCTs may be able to elicit adherence benefits beyond the techniques used in current practice.
Indeed, randomized-controlled trials have a major selection bias and cannot assess the potential adherence benefits of LAI formulations (non-compliant patients do not participate in a trial and those who accept to be included are the most compliant).
In our study, the anticipated adherence benefits observed in association with a lower pill burden is relevant but should not be construed as a suggestion that an STR is the ideal choice for the entire population of patients with HIV.
Preference for oral formulation over LAI in first-episode patients is aligned with previously reported findings that, despite the adherence benefits of LAI antipsychotics, there is resistance amongst psychiatrists to use these medications for first-line treatment [ 31, 32].
33 Future research exploring the association between reduced CINV and chemotherapy adherence would benefit from a cost analysis, which was not included in the current study.
Interventions that aim to improve medication adherence will benefit from considering the issue of adherence from a patient-centered model of care by tailoring the medication regimen to patients' life contexts, preferences and self-management practices.
Although study protocols established the timing and content of each intervention, treating clinicians were able to work collaboratively with participants and their families to maximize adherence and benefit, and minimize adverse events.
This arm aims to control for attention from study staff and general levels of participant time; to encourage recruitment, adherence and benefit; and not to influence the primary outcomes directly: no evidence suggests that health education alone will affect pain or knee-joint loads during walking.
