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What's more, study participants and the placebo group were assessed only two weeks after their last treatment, not long enough to measure adequately whether results last.
The Education Department also fails to check on its 300 private contractors adequately, whether to identify potential problems early or to instill fear of getting caught, the audit says.
But critics of the proposal say that drug and device companies have a long history of promoting unapproved drug and device uses that later proved dangerous and that allowing companies to talk about such unapproved uses removes incentives for companies to research adequately whether the new use is actually beneficial.
In his earlier decision, Judge Breyer had said the government had failed to assess adequately whether the Roundup Ready trait could be transferred to organic or conventional alfalfa, hurting sales of organic farmers or alfalfa exports to countries like Japan that did not want the genetically engineered variety.
In any case, the maintainability measure seems to reflect quite adequately whether everything has gone smoothly during the treatment process of elderly patients at the population level, as long as the potential restrictions are kept in mind.
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This general principle is stated in our guide to authors, while referees who assess our research articles are asked to consider whether the methods are adequately reported, whether the data shown include the necessary controls and are adequate to support the conclusions drawn, and whether they have been able to assess the validity of the statistics.
28 We assessed adequacy of the generation of the allocation sequence; concealment of allocation; blinding procedures; whether or not outcome data were adequately addressed; whether the study was free from suggestion of selective outcome reporting; and whether it was free from other problems that could put it at risk of bias.
Overall, the lack of information about costs and resources means that it may be difficult for funders to decide whether the qualitative research is adequately resourced, whether it is feasible to complete, or if it provides value for money.
We noted whether the allocation of patients in each trial was adequately concealed, whether patients had been described as blinded (or masked), and whether dropout was below 15%.
Without a disease-specific instrument, there will continue to be uncertainty regarding whether relevant aspects and effects of the disease are being measured adequately and whether drug therapies, or other interventions, have a net beneficial or adverse impact on HRQL.
Other findings of the report included: Auditors failed to adequately test whether seven of the 23 firms had sufficient capital.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com