Whether combination therapy proves beneficial in these patients with poor prognosis on standard therapy needs to be addressed by an adequately powered trial with strict monitoring of potentially dangerous adverse effects in this particular subgroup of severely ill patients.
Poor infrastructure and opportunity costs have meant that many people still go without life-improving medicines [ 9] and many of those who receive ART are unable to adequately adhere to the strict treatment plans [ 10, 11].
Clinical trials to clarify this situation should be well designed, adequately powered prospective studies with strict inclusion criteria, genotype testing and endoxifen levels.
Despite these difficulties, which are standard practice in these kind of trials, there was no evidence of broken double-blindness for any patient, reinforced by the strict assurance of adequately concealed random allocation by the interactive voice response system.
Future studies need to be adequately powered, should use a strict diagnosis of migraine, should include aura status, should present results for clearly defined cardiovascular events such as ischaemic stroke and myocardial infarction (not just combined end points), and should present results stratified by important and biologically meaningful modifying factors in addition to overall analyses.
"This approach relies on jurisdictions instituting strict regulatory regimes to adequately protect public safety".
It is thus much more amenable for biogeographic analysis within regions that have a complex paleogeological history, which a strict vicariance model cannot adequately address.
Although we present unique data concerning long-term clinical outcomes, adequately powered randomized trials are necessary with strict adherence to IPOC protocol to determine whether a reduction in IS by IPOC translates into improved clinical outcomes.
Because meal size [ 36], meal composition [ 37] and rate of gastric emptying [ 38] influence postprandial insulin secretion and glycaemia, a strict protocol was required with adequately trained assistance and researchers.
The claim is developed that, for ethical reasons and in order to adequately control technology, the legal system should evolve towards strict and unlimited liability for all technological activities.
