However, since optic nerve/chiasm pathologies cannot be adequately evaluated on imaging, diagnosis of SOD cannot be confidently made with imaging alone, often requiring post-natal neuro-opthalmic evaluation for final diagnosis.
Trialists may consider including well thought out and adequately powered evaluations of strategies to increase retention in randomised trials.
Trialists should consider including well thought out and adequately powered evaluations of strategies to increase retention in randomised trials with clear definitions of retention strategies and retention measures.
Granted, the individual toxicity of many, if not most, chemicals has not been adequately evaluated to provide the concentration response information required for the joint evaluation of toxicity.
In our case, the increased sample size was necessary to adequately power the evaluation of non-linearity in the MRI and Aβ load risk profiles.
While the BOT-2 provided the most evidence for valid and reliable measurement of Criterion A of the diagnostic criteria for DCD among this age group, no test adequately evaluated Criterion B. Further evaluation of motor skill assessment among the young adult population is needed.
Other aspects require further investigation and may not be adequately addressed through the evaluation of countermeasures.
These results support preclinical evidence that traditional clotting assays, such as INR and aPTT [ 9, 34, 35] may not be adequately sensitive for reliable evaluation of the pharmacodynamic effects of direct reversible factor Xa inhibitors.
The placebo group discontinuation rate in ISOLDE, EUROSCOP and UPLIFT ranged from 30% to 53%. 6 26 27 As with the protocol of UPLIFT, we have estimated a 35% discontinuation rate in our study to ensure that it will be adequately powered to enable evaluation of the primary outcome.
In contrast, HHE appears adequately suited for the evaluation of left ventricular systolic function [ 7- 12] and cardiac chamber size [ 7, 9], the identification of pericardial or pleural effusion (Table 1), and for diagnoses based on two-dimensional imaging and color Doppler mapping [ 8, 9, 12].
