"The study does not adequately control for the numerous complex factors that dictate chapter choice," he said.
Thus, controlling for census region may not adequately control for the drug overdose epidemic in Appalachia.
Observational studies should adequately control for relevant confounders (eg, baseline comorbidities) and assess effect modification in the analysis.
For example, controlling for census regions may not adequately control for geographic variations in overdose death between states in different geographic regions.
Despite this, ISS may not adequately control for severity given it does not account for multiple severe injuries in the same body region.
The majority of studies reviewed contained methodological weaknesses including; inappropriate study design, limited sample representativeness, the use of ecological data to evaluate individual behaviour change and failure to adequately control for potentially confounding variables.
Accurately measuring the volume of tissue damage in experimental lesion models is crucial to adequately control for the extent and location of the lesion, variables that can dramatically bias the outcome of preclinical studies.
Given the capability of the RV-GDT to adequately control for population admixture or substructure and analyze pedigrees with missing genotype data and its superior power over other family-based methods, it is an effective tool for elucidating the involvement of RVs in the etiology of complex traits.
While for IgG antibodies, isotype-matched controls are well accepted, when considering smaller antibody fragments it is not possible to adequately control for their biological activity through the use of archetypal isotypes, which differ dramatically in affinity, size, structure, and design.
Earlier research demonstrates increased and decreased risk of crash related to psychological distress; however, previous literature has almost entirely used retrospective study designs and has not been able to adequately control for important confounders such as exposure to driving, alcohol and drug use, or having had a previous crash.
