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In some cases, it was also difficult to determine adequate reporting for non-drug interventions (i.e. surgery, education, counselling, devices).
All trials demonstrated adequate reporting for allocation concealment, blinding, and drop-outs or loss-to-follow-up.
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In an exploratory analysis, no significant differences were found for adequate reporting of random sequence generation, allocation concealment, blinding and primary outcomes between industry and non-industry RCTs.
Weighted overall proportions in the ICTRP search portal for adequate reporting of sequence generation, allocation concealment, blinding (including and excluding open label RCT) and primary outcomes were 5.7% 95%% CI 3.0 8.4%), 1.4% (0 2.8%), 41% (35 47%), 8.4% (4.1 13%), and 66% (60 72%), respectively.
Due to their nature and methodological complexity, HEE have particular challenges for adequate reporting, which can be greater than more traditional study designs such as randomized controlled trials.
That consensus, however, should not replace missing or ambiguous data, or substitute the importance of adequate reporting that is necessary for a systematic review.
Randomization techniques also improved over time; however the overall number of adequate reporting was quite low, even for newer trials.
A certain level of trust between review committees and reporting physicians is a prerequisite for an adequate reporting procedure, as this would stimulate physicians to report their acts.
14 Below we provide the checklist text for each of the six items and their subitems, as well as explanations on the need for their adequate reporting and examples of good reporting from the published literature.
34 35 36 More than half of our network meta-analyses failed to report exhaustive searches; for those with adequate reporting, 11% searched only one electronic database (web table 6).
There are various possible explanations for the low prevalence of adequate reporting.
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