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All described molecular techniques were used for adequate mutation analysis in all available tumour samples.
An adequate mutation frequency is required to keep the number of PCR reactions associated with TILLING to a manageable number.
Adequate mutation frequency was, however, achieved through treatment of developing rice zygotes on the panicle immediately after pollination [ 29].
The resulting mutagenized sorghum population has an adequate mutation density and low cross-fertilization, providing a useful community resource for functional analysis of sorghum genes.
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Since most patients with LS develop breast cancer after the age of 50, population-based breast cancer screening programs, including mammography, appear adequate for LS mutation carriers.
This period is adequate for the mutation of new microsatellite length alleles in asexual lineages [ 48] and for sexual reproduction to give rise to diversified genotypes.
In conclusion, our comparison study does not aim to recommend a particular technology, as several technologies have been proven to be adequate for KRAS mutation testing in the clinical setting, depending on laboratory experience and expertise.
The results obtained so far indicate we can use the collected information to prioritize warning categories in an incremental strategy, allowing the reviewer to apply specific warning categories more adequate to detect mutations first by increasing the chance to analyze a true positive warning.
The GlobX gene was not used because there is no adequate calibration for its mutation rate.
Note that we have defined the terms "clone" and "sweep" in a broad way, which is adequate for the high mutation rate of influenza.
To assess the effects of different p53 mutations in cancer outcome, we firstly performed survival analysis on the MSKCC bladder cancer data set (JCO, 2013) in combination with The Cancer Genome Atlas (TCGA) patient cohorts that had higher frequency of p53 mutation and adequate patient outcome data.
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