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For the purpose this study an adequate course of treatment was defined as at least 6 weeks of treatment with haloperidol 5 mg or equivalent daily dose.
A contact, that resulted in what has been defined as an adequate course of medication is defined as successful (as defined earlier, haloperidol 5 mg or equivalent for the duration of six weeks).
However despite an adequate course of appropriate antibiotics the infection recurred as in previous reports of Bacillus central venous catheter infection [ 3].
Notably, the majority of patients are left with residual symptoms even after an adequate course of treatment with SRI medication [ 2].
Of the 186 patients who had extrapulmonary tuberculosis and were treated from 1993 through 2002, 91% successfully completed an adequate course of therapy, 76% within 12 months.
In the case of breakthrough disease activity despite a full and adequate course of a first-line preparation, switching to natalizumab, fingolimod or alemtuzumab should be considered.
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Calcium channel blockers Adequate courses of all drugs considered as first-line prophylactics for episodic migraine by international guidelines, and in addition adequate courses of at least some of the drugs considered second- or third-line prophylactic treatments.
Finally, a minority of patients who fail adequate courses of acid suppressive therapy may ultimately require anti-reflux surgery [ 24].
Furthermore, we chose not to exclude participants who had severe migraine and those who had failed adequate courses of treatment with ≥3 migraine prophylactic agents.
The patient population already failing adequate courses of azathioprine or 6-mercaptopurine is most prone to colectomy following initial response to cyclosporine (Moskovitz et al. 2006).
We defined treatment resistance as drug-resistance to three adequate courses of antidepressants from at least two different classes during the current major depressive episode [ 33, 34].
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