These 3D systems are able to inhibit the S. aureus growth and to destroy the bacterial biofilm without cytotoxic effects on human osteoblasts and allowing an adequate colonization and differentiation of preosteoblastic cells on their surface.
There was a significant decrease in colonization over time (P < 0.0001).
In contrast, intermittent carriers carry different strains, one strain at a time, at lower levels of colonization over time.
The natural history of this commensal " normal" colonization over weeks, months, and years is poorly understood.
Sampling sites on Vancouver Island have shown different patterns of C. gattii colonization over time (4 ).
Additionally, individual BXD strains exhibited different patterns of colonization over the course of the infection.
When assessing trends in S. aureus colonization over time, we compared the prevalence of colonization between 2003 04 and 2007 08 for the 8 communities participating in both sampling periods.
A few strains maintained colonization (BXD 99 and 102), others steadily lost colonization (BXD 51, 75, 96, 97), and some others showed variable colonization over the experiment (BXD 60, 62, 71, 87, 100) (Fig. 2).
A plot of the percentage of subjects documented to have cleared MRSA colonization over time demonstrates a trend toward the majority of subjects clearing colonization over the follow-up periods reported.
Furthermore, the responsive cultivar exhibited increased colonization over successive generations, while the poorly responsive cultivar exhibited declining bacterial populations over successive generations.
