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The compound exhibited high peripheral and adequate brain levels upon oral dosing in rodents.
One guess as to why scientists have struggled to build adequate brain models is that neurons — which form the basic unit of Compass — are too coarse a grain for capturing computation.
Representative compound 25 is a potent and selective M1 PAM that has well aligned physicochemical properties, adequate brain penetration and pharmacokinetic (PK) properties, and is active in vivo.
The racemic compound 15e was found to possess desirable pharmacokinetic properties, adequate brain penetration and activity in animal models of cognition.
Ventricular drainage may be required either on an emergency basis or can be inserted intraoperatively during aneurysm surgery to achieve adequate brain relaxation.
An adequate brain MRI interpretation must include at least three different sequences (T1, T2, FLAIR) in three different planes.
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The vesicular acetylcholine transporter (VAChT) represents an appropriate target to establish PET radiotracer that are adequate for brain imaging the loss of cholinergic terminals.
Regardless, the above concerns and the estimate that only about 2% of small molecule drugs have adequate blood brain barrier distribution have led to the perspective that kinases are not a promising class of central nervous system (CNS) drug development targets.
Tan et al. [ 4] found that limiting early energy deficits by providing high energy intake in association with increased protein intake during the hospital stay, may support adequate postnatal brain growth and improve neurodevelopmental indices at 3 months of corrected age.
Adequate perfusion of brain white matter depends on blood pressure and the brain's autoregulatory capacity [ 25].
When sleeping upright in a tight seat," he said, "the body has to push out adrenaline-like compounds to keep the blood flow to the brain adequate".
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