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As perampanel showed good brain uptake and adequate affinity and selectivity for AMPA receptors [8], its derivatives could be suitable PET probes for in vivo AMPA receptor imaging.
Furthermore, steel slag which is mostly disposed in landfills as waste material could be an appealing option as substitute of natural aggregates for asphalt concrete (AC) production because of its adequate affinity with asphalt binder.
In conclusion, at the cellular level, AMB8LK immunoNPs may carry drugs to desired overexpressing antigen cells with adequate affinity properties, potentially leading to improved drug therapy and reduced systemic adverse effects.
In our data, the glycans at Asn276 could be relatively more flexible, and bnAbs might need special features to gain adequate affinity to different glycans at this glycosite.
Interestingly, on the basis of our results we can argue that also the truncating substitution C261X, changing the first cysteine of ZF4 into a stop codon, generates a protein unable to recognize the DNA target with adequate affinity because it is missing the entire C-terminus, including the DNA-contacting ZF4 domain.
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Briefly, an adequate amount of affinity gel in a clean centrifuge tube was centrifuged (5,878 x g, 30 sec) and was allowed to precipitate (approximately 2 min).
In proteins containing multiple fingers, it is clear that adequate specificity and affinity can be provided by a few critical fingers, usually separated by a canonical 7 amino acids spacer [14,15].
The bivalent nature of the bivQ probe, however, was not adequate to increase target affinity, as observed for other multimeric small molecules.
In particular, cell-matrix interaction must be tightly controlled to ensure affinity is adequate for traction but not so excessive as to prevent forward migration [38], [39].
Together, these data show that, in addition to rapid catabolism of peptide-HLA complexes shown in Figure 2, the low efficacy of cross-linking by the photo-activatable peptides may hinder the production of adequate numbers of "infinite" affinity peptide-HLA complexes to generate potent cytotoxic responses.
In this microenvironment, B lymphocytes undergo a series of specialized events resulting in the production of specific antibodies with both high affinity and adequate effector function.
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