These patients are, therefore, well characterized as to their clinical and laboratory parameters, which ensures the adequacy of the study groups and controls, and allows an unbiased interpretation of the proposed biomarkers and their intra-group level variations.
Noblit and Hare's [ 15] position was that the adequacy of the study metaphors to account for the phenomena was an important quality consideration and that study quality would become apparent by how much it contributed to the synthesis.
The adequacy of the study design and the degree of control exercised in the data gathering enhanced the internal validity.
Much of this uncertainty stems from notable differences among previous studies; most importantly, the adequacy of the study design to accurately measure the impact of SMBG and the adequacy of the SMBG intervention itself.
In other words, we acquired sufficient evidence for feasibility and based on these experiences we were confident about the adequacy of our study design and data collection plan.
However, note that this category was not scored if a single polymorphism was assessed since we did not consider an adjustment for the multiple explored phenotypes or outcomes for the adequacy of the study to be necessary.
Adequacy of the study sample size for this purpose was verified via 100,000 Monte Carlo simulations, using the Hochberg (1988) Step-up Procedure to control for family-wise error rate in multiple comparisons [ 23].
However, also RECs and funding agencies need to be able to assess the key trial elements, and they may not always have sufficient expertise to assess the adequacy of the study methodology.
The extent to which the materials administered in the pilot study were well received highlights the adequacy of the modified study instruments and protocol for a full scale PRAMS surveillance system.
In the background of such an encouraging environment, the planning team's extensive and intensive workforce planning efforts and the educators' diligent and persistent educational endeavours, as depicted in this case study, ensured adequacy of a suitable workforce in health institutions.
