Cryotherapy adds further difficulties to the measurement procedure, for example, a limited data acquisition time after the cold application.
To add further difficulty, many will have a long and difficult journey towards diagnosis and proper management, with multiple attendances at their GP and A&E.
The interactive effects between climate drivers and other anthropogenic factors, such as pollution, habitat destruction and overfishing [ 20, 69, 71] add further difficulty to any interpretation of climate change effects.
And from the engineer's perspective, they write, making robots "sensitive to moral considerations will add further difficulties to the already challenging task of building reliable, efficient and safe systems".
The emergence of peta-scale systems and the upcoming manycore era brings nevertheless new challenges to computing systems and architectures, adding further difficulties and requirements on the development of the corresponding simulators.
Also, some sulfur compounds can be oxidized abiotically adding further difficulties in resolving enzymatic steps from chemical changes.
In addition, the reagents needed for microscopic examination of malaria parasite were not readily available adding further difficulties [ 27].
Systematic differences among regions in the genetic make-up that regulates metabolism of xenobiotics and reproductive functioning add further difficulties to the interpretation of heterogeneous associations.
The lack of related sensitive and specific laboratory tests adds further to the difficulty of early diagnosis.
Notwithstanding the difficulty of changing eating habits, this study adds further support to the need for targeting in elaborating health and nutrition campaigns.
