The simplex pre-optimization addresses the observation that typically in direct gradient-based optimizations, due to the large size of the search space, the majority of the numerical effort is spent in 'getting off the ground'.
A recently published model by Geier et al. [24] did not describe the spatial arrangement of domains, but addressed the observation that SCD and OC sizes vary strongly under changing environmental conditions.
This is asked in part to address the observation that the mutations generated to 'destabilize' the apo-LapD-output domain did not make it constitutively active as predicted.
Confirmation should address the observation that the performance of the control arm in both TIVO-1 and AMG 386 achieved the best PFS values for sorafenib alone, exceeding 9 months (Procopio et al, 2012).
To address the observation that strain 4b CLIP80459 grows more efficiently inside the host than strain 4b F2365, we performed a direct comparison of the transcriptome data derived from these two strains.
Importantly, we address the observation that organisms consist of many discrete evolutionary units: open reading frames, operons, plasmids, chromosomes and in some cases plastids and other organelles, each with discrete and possibly different evolutionary histories.
Major concerns raised and suggestions for revision: 1) The authors should explicitly address the observation that, while galectin-8 binds to receptors that both negatively and positively regulate osteoclastogenesis, the net effect in galectin-8 transgenic mouse is the loss of bone mass.
A nontrivial proportion of the multicase breast cancer families studied by Kainu et al will occur by chance alone, as demonstrated by simulation studies [ 2] that addressed the observation from population-based studies that the majority of hereditary early-onset breast cancer is sporadic.
'Pan'-histone demethylase inhibitors 80 and 81 (Fig. 13) targeting both KDM1 and JmjC KDMs were synthesised in an effort to address the observation that both KDM1 and KDM4 are coexpressed and colocalise with the androgen receptor in prostate cancer [152].
Addressing the latter point, observations posted on eBird (ebird.org) confirm observations of Western Scrub-Jays in southeastern Arizona and northern Sonora (in the vicinity of the genetic break), but these records could represent wandering individuals.
