This work addresses the differentiation of the inverse coupling matrix with respect to a coupling or damping loss factor.
To address the differentiation potential of the GPS niche, we isolated GRFa2+ individual cells and maintained them as a suspension culture in a serum-free conditioned medium (SpherM).
The first reports on the clinical application of FDG-PET in colorectal cancer addressed the differentiation between scar tissue and local recurrence in rectal cancer [ 17, 18].
Moreover, the neuropathological studies of DRN have not addressed the differentiation between paranoid and residual schizophrenia, which are substantial diagnostic subgroups with distinct clinical presentations (the former being characterised by predominantly psychotic and the latter by predominantly negative symptoms) and distinct abnormalities in the serotonergic system [for reviews see: 1, 49].
Specific investigations addressing the adipogenic differentiation capacity of adipose derived MSC assessed the expression of peroxisome proliferator activated receptor γ2 (PPARγ2) which plays an essential role in adipogenesis and has been widely accepted as a marker for terminal adipogenic differentiation [ 53, 54].
Indeed, there is a growing body of literature addressing the induction of OPC differentiation by stimulation or inhibition of a variety of cell signaling pathways (Deshmukh et al., 2013; Jepson et al., 2012; Medina-Rodriguez et al., 2013; Schmidt et al., 2012; Xiao, 2012; Zuchero & Barres, 2013).
In the same year, Weimann et al. [ 45] also addressed the fusion/trans-differentiation conundrum using GFP-positive sex-mis-matched BM transplants in mice.
To address functionally the differentiation potential of cells growing in these structures, we dissociated 60-day-old ex vivo co-cultures and subjected the resulting single cells to colony formation assays.
We did not address whether the differentiation of ball mutant cells is fully completed like in the respective wild type lineages in systems other than the adult female germline, but we found, irrespective of the system we looked at, that BALL is not strictly required as proliferation factor.
Even though several works have extensively investigated different QoS enhancing mechanisms supporting service differentiation, few research works addressing the application of feedback control methodologies are available.
