The NIH is combating errors by requiring investigators to follow new guidelines addressing scientific premise, experimental design, biological variables, and authentication of reagents.
So it's certainly fair to address the premise of Mr. Wagoner's concern head on.
In vivo and in vitro studies using an ovine model system were designed to address a premise that oxidative distresses to DNA inflicted upon ovarian surface epithelial cells within a limited diffusion radius of the ovulatory site of follicular rupture, if gone uncorrected by p53-dependent cycle arrest/repair pathways, could yield a progenitor of tumorigenic potential.
Hence, most studies failed to address the premise of confounding by indication that is, the relationship between the diagnostic pathway (and hence the time interval) and prognosis.
To address this premise, we sought to validate this possibility using prostate cancer cells as well as hepatocellular carcinoma and fibrosarcoma cell models and their respective PACE4-knockdown (shPACE4) counterparts.
"In every board room for every major restaurant brand in the country… the number one conversation surrounds the topic of how are we going to address [off-premise diners]." Collins' company just raised $10 million in a funding round led by GV, the investment arm of Google parent company, Alphabet.
And some of the premise is addressing what is already a need today.
As predicted, ICS necessity beliefs and concerns were related to reported adherence, confirming the premise that addressing these might improve adherence and consistency with NICE guidance 8 22 and a recent meta-analysis.
Detailed in the flagship report, 'Progress for Children: Achieving the MDGs with Equity,' the approach is based on a simple premise: that addressing the needs of the poorest of the poor is key to meeting the development goals and reducing global injustice.
Nor are the satiric possibilities of the film's premise addressed, and the result is a political comedy that refuses to address a single real political topic.
