Only one study addressed correlation of sVCAM-1 with clinical severity scores, and reported modest correlation with SOFA and APACHE II [ 77].
Cattaert et al. [ 19] have developed FAM-MDR method, which addresses correlation between observations in family-based studies and extends the model based MB-MDR approach [ 24] to handle continuous covariates and continuous phenotype.
Numerous past studies addressed correlations between intrinsic disorder and individual PTMs in eukaryotic proteins.
Some phylogenetic methods have been developed to address correlations caused by shared evolutionary history for phenotypic and sequence data [ 95].
Also, several studies addressed correlations between intrinsic disorder and the universal Lys modifications, such as acetylation and methylation.
Although changes in FLT SUV between the first two scans proved predictive of response, the study was not conducted in the neoadjuvant setting and did not address correlations with Ki-67, but rather the tumour marker CA27.29.
MEMs, widely used to address correlations in repeated-measures and multi-level data (Laird and Ware, 1982), are an alternative latent variable modeling strategy that has been described for characterizing association between multiple SNPs, within and across genes, and a measured trait (Foulkes et al., 2005; Goeman et al., 2004; Foulkes and De Gruttola, 2002).
Although data from humans addressing this correlation are still limited, one small study clearly demonstrated that the magnitude of the ESAT-6 specific IFN-γ response in recently exposed healthy contacts correlated with disease status one year later [7].
The only published two previous studies addressing the correlation of OCT parameters with BPF included only a limited number of patients (between 18 and 40) or inhomogeneous disease courses and did not account for within-patient inter-eye relations [19], [20].
