The IASLC is determined that over future revisions these shortcomings will be addressed as prospective data are accrued.
Finally, tapering bDMARDs was addressed, as new data had become available (item 12) that suggest that, once low disease activity and, especially, remission is sustained, a dose reduction of bDMARDs will allow maintenance of the good outcome.
Since traditional supervised classifiers cannot scale large datasets, the supervised classification for the POD problem should be addressed as a big data classification problem according to [ 31– 33] and big data solutions should be applied for binary classification in imbalanced data such as the ones presented in [ 34] based on MapReduce [ 35].
On the other hand, an application that is addressed as a DICOM data processor will have more advanced options to perform the de-identification task since that is one of its intended uses.
In addition, the question of whether it is FTH (mammography, cytology or core biopsy) or surgical intervention that is important can be addressed, as menstrual cycle data were collected for each intervention (including further surgery), making this study unique.
Several open issues caused by the big data will be addressed as the platform/framework and data mining perspectives in this section to explain what dilemmas we may confront because of big data.
According to Scutchfield et al, there are major areas of concern that must be addressed, such as data collection on structure, process and results, and standardization of data regardless of where or by whom it is collected so that it is well understood by all public health staff involved [7].
12 This might be an important issue to address as our data suggest that auto-fluid balance management is more difficult than auto-appendectomy, which has been successful in 100% of published attempts during the past five decades.
The manuscript has been improved but there are some remaining issues that need to be addressed, as outlined below: 1) Data are added to show SIGN-R1+ staining of isolated LN macrophages by fluorescence microscopy of sorted cells.
Therefore, understanding whether or not NF-κB p65 is involved in IFN production to RV is extremely important and this key issue is yet to be addressed as there are no data reported on the causal role of p65 or type I IFN in lung host defence against RV infection using in vivo human and mouse models of RV.
