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To date, only one study has addressed a role for microRNA in vascular development during branching morphogenesis of the lung, where miR-221 and miR-130a appear to have opposing effects on tube formation and migration of mouse foetal lung endothelial cells [25].
No reports have addressed a role for olprinone in pathophysiology of SCI.
We addressed a role of nucleolin in cell differentiation and identified the transcription factor Stat1 as a novel and specific binding partner of nucleolin in hematopoietic cells.
Notwithstanding, fewer studies have addressed a role for abnormal demethylation in cancer, although hypomethylation of the genome has been increasingly recognized as a cancer-linked trait, including in breast cancer [ 53, 54].
Reviewer #1: In this manuscript by Wan et al., the authors have addressed a role for the neurotrophins NT-3 and BDNF in the postnatal ear by inducibly deleting or overexpressing NT-3 or BDNF in defined cell populations early in neonatal life.
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Our goal was to address a role for PP1 in platelets using a genetic approach.
Further studies addressing a role for SIRT2 in regulation of mitosis by Aurora A or B mitosis might uncover a mechanism for the observed multinucleation.
Despite the presence of CD34 on both the vasculature and tumor-infiltrating immune cells, our study is the first to address a role for CD34 in the tumor microenvironment and highlight a tumor cell-extrinsic function for CD34 in tumor development.
To further address a role of PGC-1α in atheroprotection we investigated oxLDL accumulation in macrophage cells transfected with PGC-1α.
2) To more convincingly address a role for snoRNA/possible other RNAs associated with DKC1-containing complexes, the authors should treat their native complex with micrococcal nuclease.
As a first step towards addressing a role of selective macroautophagic mitochondrial removal in sustaining essential biological processes in yeast, we evaluated the importance of macromitophagy in longevity assurance.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com