The phrase "address the substantial challenges" is correct and usable in written English.
It can be used when discussing the need to confront or deal with significant difficulties or obstacles in a particular context.
Example: "In order to move forward, we must address the substantial challenges that lie ahead in our project."
Alternatives: "tackle the significant issues" or "confront the major obstacles".
Along with the potential for fundamentally new insights into cancer research, the Bridge Project addresses the substantial challenge in "bridging" a significant divide – in scientific language, experimental approaches, and traditional expertise.
High-quality, credible science from locally relevant studies is essential to address the substantial air pollution challenges in Asia.
"Speaking up is a key component of safety culture, yet our study the first to our knowledge to address this issue revealed substantial challenges for patients and families speaking up during an ICU stay," said co-lead author Sigall K. Bell, associate professor of medicine at HMS and the director of patient safety and discovery at OpenNotes at Beth Israel Deaconess.
It also said Brexit would dominate legislative priorities, so there could be limited capacity to address "substantial" challenges.
Achieving universal health care is being addressed through the ACA in the US, but substantial challenges remain.
In addition, addressing the substantial disparities in health care resources between provinces is regarded as the South African health sector's major challenge [ 19].
An assessment of the state of midwifery in Morocco revealed that the profession faced substantial challenges related to education and other issues that need to be addressed.
Two of the non-concrete prototypes presented "substantial" challenges, and the remaining two had "moderate" challenges.
14 The REACT approach does, however, face substantial challenges (table 2 lists opportunities and challenges, with strategies to address them, for REACT trials conducted within EHR databases).
