Antagonists addressing selectively NMDA receptors containing the GluN2B subunit are of particular interest for the treatment of various neurological disorders including neurodegenerative diseases.
Negative allosteric modulators addressing selectively the ifenprodil binding site of GluN2B subunit containing NMDA receptors are of major interest due to their neuroprotective potential accompanied by few side effects.
Particular emphasis is given to highly cell type-specific modifications of these mechanisms that potentially may allow to addressing selectively non-neuronal and neuronal cholinergic signalling by pharmacological intervention.
Both work at the IP address level, selectively passing or blocking data packets.
The results highlighted that proper substituents in position 2 of the phenoxy moiety of 3 selectively address the ligands toward 5-HT1A receptor with respect to α1-ARs and D2-like receptor subtypes.
The analysis critically highlights the dramatic quality inherent to moral scenes, and depicts and discusses how visitors' texts selectively address the moral Actor, Action and Motive as parts of the social moral drama they evaluate.
Great progress has been made in the clinical translation of several therapeutic strategies for spinal muscular atrophy (SMA), including measures to selectively address Survival Motor Neuron (SMN) protein deficiency with SMN1 gene replacement or modulation of SMN2 encoded protein levels, as well as neuroprotective approaches and supporting muscle strength and function.
Brains decompose the world into discrete objects of perception, thereby facing the problem of how to segregate and selectively address similar objects that are concurrently present in a scene.
Connexin57 (Cx57), a gene that encodes a gap junction protein, is exclusively expressed in retinal horizontal cells, so no other cell classes are affected [27], making this mouse line a powerful model to very selectively address this question.
To selectively address stromal gene expression changes during cancer progression, we performed cDNA microarray analysis of laser-microdissected stromal cells derived from prostate intraepithelial neoplasia (PIN) and invasive cancer in a multistage model of prostate carcinogenesis.
