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Isobolographic analysis yielded most of the data points within the envelope of additivity, denoting additive interactions in both cell lines.
These data are an important addition to studies showing significant additive interactions between SE and ever smoking in the risk of ACPA-positive RA [ 2, 3].
Additive interactions are based on either similar or dissimilar non-interactive effects of chemicals.
This methodology has allowed for a rigorous statistical evaluation of potential departures from additive interactions in endocrine active mixtures.
Synergistic and additive interactions were considered, which means greater threat to organisms when exposed to multiple estrogenic endocrine disruptors.
Lu et al. (2008) reported six epistatic loci with additive and additive interactions for grain Zn, which accounted for 50.2%% of the total heritability of the trait.
The theoretical additive interactions were calculated from the concentration-response curves of each drug as a single agent.
Importantly, because the algorithm relies on additive interactions, it does not require structural knowledge about the target.
Expressing CaV1.2 channels that lacked both N and C termini reduced gluconate inhibition to ∼25% consistent with additive interactions between the two tail regions.
Purely additive interactions are represented graphically as areas in grey, indicating that they do not differ from the calculated additive effects.
Combination analysis identified additive interactions between ibandronate and ER antagonists.
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