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Interactive effects of any suspected risk factors were evaluated by assuming an additive interaction relation.
To explore the additive interaction of patient-based characteristics that may help to inform treatment.
Synergy in a combination is due to not purely additive interaction between the biological functions of the component compounds.
For BECN1 knockdown combined with ICI treatment, RI = 1.23 suggests at least an additive interaction.
Testing for additive interaction was not performed.
An RERI = 0 indicates no additive interaction, an RERI>0 suggests positive additive interaction, and an RERI<0 suggests negative additive interaction.
Results of additive interaction are shown in table 3.
RERI >0 or AP > 0 indicates significant additive interaction.
An RERI >0 indicates a synergistic, additive interaction.
Under an additive interaction, OR11 – OR10 – OR01 + 1 = 0.
bStatistically significant additive interaction by maternal age group.
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