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Multimorbidity results in complex disease patterns that may have multiplicative, and not merely additive, consequences on health outcomes; and could diminish patients' ability to manage their condition and enact behavior changes that may be required to improve health.
An important implication of this postulate is that, in studies evaluating several of these hormones, it would be worth considering assessing their additive consequences for breast cancer risk (e.g. by expressing each of these hormones in terms of the corresponding standard deviates).
In conclusion, this study provides evidence that genetic and conventional cardiovascular risk factors tend to have additive consequences on CHD, an issue that may be of preventive importance when genetic predisposition could not be assessed through an ad hoc genetic risk score but simply through a positive family history.
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As a consequence of this additive effect, response latencies were faster for purely verbal audiovisual pairs (VV in Table 1) relative to all other conditions.
Efficacies of sensitization were determined by comparing the decrease in cell viability following combination treatments (i.e. drug in combination with TRAIL) to the reduction in cell viability as a consequence of the additive effect of single-agent treatments (drug alone + 10 ng/mL TRAIL alone).
The consistent selection of the HOXA cluster on chromosome 7p15 in the sequential model building method, suggests that down-regulation of these genes is an additive event and not simply a consequence of rearrangements on chromosome 8.
As a consequence, delirium has no additive effect in the predictive value of the APACHE-II score.
This indicates an additive effect.
Furthermore the authors suggested that, since most (82%) of the differentially expressed genes exhibited non-additive inheritance patterns, the consequences of introgression would likely to be difficult to predict [ 41].
In partial support of this hypothesis, they showed [ 30] that maternal hyperglycemia due to GCK mutations was associated with an increased birth weight that was a consequence of additive effects of the maternal and the fetal GCK genotype.
However, the influence of fishing on the amount of additive genetic variance and its consequences for the reversal of fisheries-induced adaptations have not yet been investigated.
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CEO of Professional Science Editing for Scientists @ prosciediting.com