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By sequencing different sample types we were not only able to scan for differences between the twins, but additionally search for tissue-specific variants in the bowel tissue directly affected by the inflammation of CD.
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Two review authors [ 97, 103] additionally searched for other reviews and guidelines and used these to reach their conclusions.
The websites of the European League Against Rheumatism and American College of Rheumatology were additionally searched for relevant information concerning the clinical trials.
We additionally searched for evidence of direct physical interactions for the enhancer-TSS pairs calculated above by using ChIA-PET data for RNAPII [ 41].
Additionally, searches for ectoparasites remained negative in several "suspect" sheep tested at various time points throughout the studies, suggesting that our sheep remained ectoparasite free.
Therefore, we additionally searched for putative palindromic AtfA/Sko1 binding sites (5′-TKACGTMA-3′) in the promoter regions of the cluster (Proft et al., 2005).
We additionally searched for papers relevant to this set of genes using Textpresso for Arabidopsis and Google Scholar (scholar.google.com) but were not able to retrieve any additional references that could be used to annotate gene function.
We also analysed all promoters for putative AtfA binding sites and revised the Results section accordingly: "Therefore, we additionally searched for putative palindromic AtfA/Sko1-binding sites (5′-TKACGTMA-3′) in the promoter regions of the cluster (Proft et al., 2005).
We additionally searched for distant eQTLs in 1 or more dataset with P < 5E-8 that overlapped long range regulatory interaction sites via ENCODE chromosome conformation capture carbon copy (5C) data [ 50].
Since the necessity (and ethical acceptability) of a placebo arm may be questioned as an efficacious intervention had been identified, we additionally searched for trials that did not include a placebo arm.
A first-level extension is to combine information from both phenotype groups (affecteds as well as unaffecteds) through This aims at additionally searching for unusual IBD-sharing within the set of unaffecteds.
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CEO of Professional Science Editing for Scientists @ prosciediting.com