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For rs7498665 an asymptotic, 2-tailed p-value for the transmission disequilibrium test (TDT) was additionally calculated with PLINK.

To give a rough estimate of their predictive power as a screening tool, a logistic regression was additionally calculated with a combination of those independent variables in the data set of Study II which had revealed significant associations with case-control status, that is, hair color, skin photosensitivity, and handedness.

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In case of a significant interaction effect containing the factor Pulse, we additionally calculated ANOVAs with the standard SICI measure (ratio of conditioned and unconditioned MEP response).

With respect to a cumulative binomial distribution (CBD), we additionally calculated P-values together with the corresponding q-values (Table S2) yielding a probability of 0.12 for any probe set to be differentially expressed with senescence and a probability of 0.11 for a probe set to be differentially expressed with oxidative stress.

Checking possible nesting-effects of class-affiliation, we additionally calculated the null model with repeated measures nested within classes.

Mackiewicz and colleagues calculated the b value for three successive DnaA boxes (average of two distances), whereas we additionally calculated for four and five successive boxes, with no clear correlation with the identified binding sites.

Bootstrap values were additionally calculated to infer branch support with 1000 replicates.

For HR, 3-hour means were additionally calculated by the same method (comparison with the corresponding baseline daytime data for each individual) from the first day after an experiment to allow construction of more detailed time courses of changes.

Graphical summaries of the correlations coefficients for strands four to nine are shown in Fig. 2 and Supplementary fig. 3. Normal modes and trajectories of mode displacements were additionally calculated from the same structure used in the elastic normal mode calculations using GROMACS with the CHARMM27 force field combined with the OBC (Onufriev, Bashford, Case) implicit solvent model51.

We additionally calculated the potential pRBC units and cost savings that may be realized with this reduction of overall utilization of blood.

We additionally calculated the matrix of genetic distances between individuals and compared these distances with geographic distances calculated from longitude and latitude of subject locations, using the Mantel test.

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