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An additional unanswered issue is why ETVr substitutions leading to virologic breakthrough occur only in LVDr HBV with the M204V+L180M substitutions and not M204I HBV [10].
Further trials of multidisciplinary rehabilitation should look at additional unanswered questions, rather than just a comparison with usual care or a physical treatment.
One of several additional unanswered questions is whether the PMC are transcriptionally silent during meiosis, an assumption based mainly on analyses of animal meiotic cells.
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An additional important unanswered question is whether the approach described by Puppe and colleagues will also show utility in the therapy of sporadic basal breast tumors, many of which have decreased BRCA1 activity as a result of gene methylation [ 14].
A number of additional questions remain unanswered.
Through an iterative series of participatory meetings, the partners reviewed the questions, provided responses, sought additional data for unanswered questions, and finally confirmed the responses on the completed instrument.
Further evaluation (through additional research) of the unanswered questions as to who should receive specialist services and which forms of comprehensive geriatric assessment are most appropriate to which inpatient setting (acute or post-acute) are a priority.
Although many advances in our understanding of the soil system have been made since the late 1800s, when soil science blossomed into a scientific discipline in its own right, there are still many unanswered questions and additional needs in soil mapping, classification, and pedologic modeling.
Board members demanded that Verizon file additional papers to resolve several unanswered questions about the bid, such as whether second telephone lines for home computers would have to be subject to the same charges and whether the plan unfairly hurt a particular customer class, like the elderly.
Therefore, issues such as helper node competition and whether the shortest path can be decided without additional control frame exchanges remain unanswered.
A comparatively low response rate (57%) and unanswered questions present additional limitations to our study.
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