Sentence examples for additional somatic mutations from inspiring English sources

Frank leukemia was detected only after acquisition of additional somatic mutations, most notably in NOTCH1 and deletion of the CDNK2A tumor suppressor gene.

During the establishment of the cell line, additional somatic mutations occurred in the polyglutamine region (patterns 11 and 16).

While minor, these subpopulations contained many additional somatic mutations, including shared mutations in cancer genes including NOTCH1, CCND3, and BCOR.

Therefore, it seems that cluster M diverged from the common ancestry clone of cluster P1 with few additional somatic mutations.

Both Tier 1 cell lines are cancer-derived, which may present additional somatic mutations, further complicating protein expression.

Following the discovery of JAK2V617F mutation, additional somatic mutations have been found and implicated in MPN pathogenesis, particularly in cases of JAK2-negative disease (Table 4).

There is a continuing effort to enter additional somatic mutation data in to COSMIC.

In the current study, the nontumor liver tissue expressed LFABP, demonstrating a residual basal HNF1A activity; it was null in tumor hepatocytes, suggesting that an additional somatic mutation may have occurred to completely inactivate HNF1A.

The corresponding quantity for the mutator pathway is then the probability weighted integral of all the possible pathways with an additional somatic mutator mutation occurring at any time between 0 and T [15].

Additional somatic point mutations in pediatric-type follicular lymphoma were observed in genes involved in transcription, intracellular signaling, and cell proliferation.

Individuals with a germline APC mutation develop multiple adenomas as a result of inactivation of the remaining allele in the colorectum by additional somatic APC mutations or loss of heterozygosity (LOH) at this locus.