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With the redundancy of the overlapping probes in the lettuce array, the need for additional replication was reduced because they provide technical replicates within a chip.
In addition, our sample size is relatively small, thus additional replication studies using more SNPs in large non-Asian samples are needed.
This variant did not remain significant when additional replication samples were examined.
Therefore, these exploratory results were provided as potentially interesting findings worthy of additional replication efforts.
With the additional replication sample, the joint analysis marginally strengthened some of the SNPs in the GWAS.
Although Tan et al. [33] have also reported association of variation in the KCNQ1 locus and impaired beta-cell function in 3734 Asians additional replication attempts in large independent studies with careful measurements of stimulated insulin release are warranted.
Similar(13)
Saturation was reached after 50 bootstrap replications, with additional replications not yielding significantly different results.
Nevertheless, further additional replications are required to confirm or exclude the current findings.
Additional replications on this smaller sample set could then be performed to confidently exclude the false positive results.
A burn-in of 1,000 replications was discarded and 5,000 additional replications were analyzed.
Additional replications would be required to confirm these associations in humans.
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