In general, the few studies that have investigated the issue of whether the metabolic syndrome adds additional prediction for incident diabetes once its components are accounted for have concluded that this is not the case.
This estimate of δ, analogous to the estimates that could be experimentally obtained in actual populations, was used to compute additional predictions of the evolution of fitness for N = 10 or N = 50 lines with Equation 4.
In particular, for DREAM2 the winning approach was fitting ordinary differential equation (ODE) models [27], [30]; for DREAM3, instead, the best method was based mainly on finding significant deviations from wild type in knockout data (so using the same primary source of information of our algorithm), but also applied ODE models on the time series for additional predictions [31].
Because increases in effective population sizes should influence aspects of sequence evolution as well as genome structural evolution, our hypothesis generates additional testable predictions, for example, that rates of amino acid replacement substitutions (relative to rates at silent sites) should be elevated on internal branches of the mammalian phylogeny prior to the KT boundary.
Finally, pooling of cardiovascular phenotypic data in children with other cohorts may provide opportunities for additional prediction model development, validation and subsequent secondary preventive strategies.
Additional prediction models will be derived for secondary outcomes of interest, defined in table 2. CVDPoRT will be derived and validated using secondary data.
In addition we generated predictions for an additional 20 compounds for which targets were either known or unknown [30].
Additional File 1 shows predictions for related data on tumorigenic breast cancer and smoker lung cancer samples (Additional file 1, Supplementary Tables S3 and S4).
We then make predictions for additional possible links where interactive network structure is less clearly resolved.
For model predictions for additional PCB congeners (28, 53, 101, 118, 138, 180), see Supplemental Material, Figure 3.
