Sentence examples for additional pivotal from inspiring English sources

However, there remains a need for additional pivotal studies on diacerein, particularly on knee OA structure.

However, the high expression levels of ALDHs in various tissues suggest that these enzymes have additional pivotal roles.

Although the peculiar role of B cells in autoimmunity is the production of autoantibodies, growing evidence suggest that B cells may also exert additional pivotal functions such as antigen presentation and release of specific cytokines with immune regulatory, proinflammatory, polarizing and tissue-organizing functions [ 7, 8].

Moreover, it is envisaged that this concept could have broader significant therapeutic implications in breast cancer because it may prove applicable to other erbB tyrosine kinase receptors and additional pivotal chaperone-controlled oncoproteins, for example insulin-like growth factor-1 receptor, Raf-1, mutant p53, and steroid hormone receptors.

An additional pivotal role of IL-15 as a link between the innate and adaptive immune system was recently suggested from the observation that activated T cells express Toll-like receptor 2, a co-stimulatory receptor that acts together with IL-15 in maintaining T cell activation [ 9].

These issues in fact only recently emerged as additional, possibly pivotal, protagonists in the busy scenario of NAFLD pathogenesis not only in animal models [ 2] but also in humans, including childhood [ 3].

The important role of environmental covariates in limiting prediction uncertainty suggests including additional covariates is pivotal to improving POLaccuracycuraccuracy

Hence, additional behavioural data are pivotal for a full understanding of the evolution of these darts.

Taken together, the identification of miR-29b as a tumor-suppressive miRNA in human CRC that acts by repressing Tiam1 provides additional evidence of a pivotal role for miRNAs in CRC tumorigenesis and progression.

In our recent study, miR-133a was identified as a tumor-suppressive miRNA in human CRC that acts by repressing LIM and SH3 protein 1, which has been previously identified as tumor metastasis-associated protein, provides additional evidence of a pivotal role for miRNAs in CRC tumorigenesis and progression.

All the obtained compounds, 1a 1e, exhibit distinct 3-D polymeric architectures either in the form of stacked layers or host-guest networks in which water molecules play a pivotal role providing additional stabilization by coordinate bonds as well as hydrogen bonds.