Sentence examples for additional mismatches from inspiring English sources

Additional mismatches result in measureable signal but progressively larger decreases in intensity.

Manipulation of the algorithm to include additional mismatches would, in principle, allow utilization of more sequence reads, reducing the number of sequence fragments needed for accurate polymorphism prediction.

For analysis we used only uniquely mapped reads, which were defined as reads having at least two additional mismatches in the second best hit compared to the best hit.

The selective shR-P16 was further studied by testing whether enhanced discrimination was possible by incorporating further modifications within this shRNA guide strand, including shifting the position of the secondary mismatch and the inclusion of additional mismatches (Figure S2A).

These criteria included the allowance for one mismatch in the region complementary to nucleotides 2 to 12 of the miRNA, but not at the cleavage site (nucleotides 10 and 11), and three additional mismatches between nucleotide positions 12 and 21, but no more than two continuous mismatches within this region.

Here, alternative solutions such as switching the template strand to avoid base substitutions close to the 3' end of the allele-specific primer and/or lengthening it to overcome the hybridization destabilizing effects of additional mismatches with the more central part of its binding sequence might also be insufficient.

Another set of primers was designed to have an additional mismatch at the second nucleotide from their 3′ termini.

Protocols were optimized for 14 frequent SNPs in BRCA1 and 2. Two probes contained an additional mismatch to detect a rare polymorphism a few nucleotides upstream.

While the quantity of nursing homes is still inadequate with an additional mismatch problem between the supply and demand, the quality of care in most nursing homes is suboptimal.

For example, additional mismatch on "long arm" has no effect on MMES score.

This means that for a probe, of length 25, designed to have only the central base probed that there will frequently be at least one additional mismatch per probe and possibly several.